Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
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Because of the potential for serious adverse reactions rein nursing infants from methadone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
The use of methadone hinein patients already known to have a prolonged QT interval has not been systematically studied.
Teratogenic Effects. Pregnancy Category Kohlenstoff – There are no controlled studies of methadone use hinein pregnant women that can be used to establish safety. However, an expert Bericht of published data on experiences with methadone use during pregnancy by the Teratogen Information Struktur (TERIS) concluded that maternal use of methadone during pregnancy as part of a supervised, therapeutic regimen is unlikely to pose a substantial teratogenic risk (quantity and quality of data assessed as “limited to ritterlich”). However, the data are insufficient to state that there is no risk (TERIS, last reviewed October, 2002). Pregnant women involved rein methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result rein toxic effects.
Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration.
The physician should not confuse such symptoms with those of narcotic abstinence and should not attempt to treat anxiety by increasing the dose of methadone. The action of methadone in maintenance treatment is limited to the control of narcotic withdrawal symptoms and is ineffective for relief of general anxiety.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
are allergic to methadone or anything else hinein methadone hydrochloride tablets. Teich the end of this leaflet for a complete Tücke of ingredients.
Do not take any medicine while using methadone hydrochloride tablets until you have first talked to your doctor or pharmacist. They will Beryllium able to tell you if it is safe to take other medicines while you are using methadone hydrochloride tablets.
Rein vitro results suggest that methadone undergoes hepatic Nitrogenium-demethylation by cytochrome P450 enzymes, principally CYP3A4, CYP2B6, CYP2C19 and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with CYP inducers of these enzymes may result rein a more rapid metabolism and potential for decreased effects of methadone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects.
This drug can make you very drowsy. You shouldn’t drive, use machinery, or do other activities that require alertness after you’ve taken this drug.
Overdose hinein children warning: Children Methadontabletten online kaufen World health organization accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.
Methadone may Beryllium expected to have additive effects when used rein conjunction with alcohol, other opioids or CNS depressants, or with illicit drugs that cause central nervous Gebilde depression. Deaths have been reported when methadone has been abused in conjunction with benzodiazepines.
There is considerable variability hinein the appropriate Tarif of methadone taper in patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should Beryllium less than 10% of the established tolerance or maintenance dose, and that 10 to 14-day intervals should elapse between dose reductions.